Fig 1.
PRISMA flow diagram for article screening and selection process.
Table 1.
Summary of the characteristics of the 10 trials included in this research.
Fig 2.
Summary diagram of risk of bias percentile chart for RCTs.
Table 2.
Results of quality assessment using Newcastle-Ottawa scale for cohort studies.
Table 3.
Summary of data on serological response rates of interventions at 6-month follow-up.
Table 4.
Summary of data on serological response rates of interventions at 12-month follow-up.
Table 5.
Results of the head to head meta-analysis on serological response at 12-month follow-up.
Fig 3.
The network diagram of eligible studies.
Fig 4.
Summary of the network meta-analysis on estimates for the serological response rates at 12-month follow-up.
CI, confident interval; PrI, prediction interval.
Fig 5.
Funnel plot of the included studies reporting on the serological response at 12-month follow-up.
Funnel plot provides a scatter diagram which could visually assess publication bias. In the absence of bias the plot will resemble a symmetrical inverted funnel.
Fig 6.
Summary of the network meta-analysis on estimates based on different penicillin regimens.
BenPen, benzathine penicillin G; Ceftr, ceftriaxone; Doxyc, doxycycline; Tetra, tetracycline.
Table 6.
Results of the head to head meta-analysis on treatment failure at 12-month follow-up.