Fig 1.
Flow diagram of target polymorphism selection.
The diagram indicates inclusion and exclusion criteria for selection of target polymorphism.
Table 1.
List of 53 polymorphisms in 33 genes included in this study.
Table 2.
Characteristics of the participants in this study.
Fig 2.
Correlations between rs11264422 genotype and continuous outcomes.
There were significant associations between rs11264422 genotype and (A) circulating CD34+ cells/μL (raw P = 0.03), (B) total CD34+ cells/kg (raw P = 0.008), and (C) product CD34+ cells/μL (raw P = 0.003) in the Korean set (gray-colored bar). However, no statistically significant association was found between rs11264422 genotype and circulating CD34+ cells/μL in the European set (solid-lined bar). Mobilization outcomes were applied natural log transformation, due to the skewed distribution.
Fig 3.
The rs11264422 genotype distribution of participants in the Korean set, classified by circulating CD34+ cell count.
Superior mobilizers (> 200 cells/μL) had 66.7%, 12.0%, and 5.8% frequency rates in AA, TA, and TT genotypes, respectively. Poor mobilizers (< 20 cells/μL) had 25.0% and 12.0% frequency rates in TT and TA genotypes, respectively.
Table 3.
Association of rs11264422 with mobilization outcomesa.
Table 4.
Factors associated with mobilization outcomes in the univariate analysisa.
Table 5.
Factors associated with log-transformed mobilization outcomes in the multivariate linear regression analysis in the Korean set.