Fig 1.
A: Premature infants born at 27 weeks gestation at his first day of life. Normal tracing for age, note the cycling of the lower border of the aEEG tracing. Different patterns can be depicted in this tracing: Low discontinuous (black stars), high discontinuous (white arrows) and also short periods of continuous activity: black arrows. B: Premature infants bore 27 weeks gestation at his first day of life. Depressed tracing consisting of burst suppression pattern with a short period of isoelectric pattern (arrow).
Table 1.
Maternal and neonatal clinical characteristics.
Fig 2.
The distribution of placental lesions among cases.
AFI- Amniotic Fluid Infection; MUP-Maternal Under Perfusion; FVTOD-Fetal Vascular Thrombo-Occlusive Disease.
Fig 3.
Association between placental histology and depressed aEEG—According to the neonatal percentage of daily depressed aEEG during the first three days of life.
Significant association is demonstrated between MUP of a vascular type and neonates with the most depressed aEEG recording during the first 3 days of life. AFI- Amniotic Fluid Infection; MUP-Maternal Under Perfusion; FVTOD-Fetal Vascular Thrombo-Occlusive Disease.
Table 2.
Maternal and neonatal clinical characteristics and placental oathology.
Table 3.
Association between placental histology and absence of sleep cycling.
Table 4.
Daily percentages of depressed infant brain activity according to placental histology.
Fig 4.
Distribution of placental lesions within thirtiles of cerebral activity.
Infants with placental lesions consistent with vascular MUP were more likely to be in the highest thirtile of depressed cerebral activity. AFI: Amniotic Fluid Infection. MUP: Maternal Under Perfusion. FVTOD: Fetal Vascular Thrombo-Occlusive Disease.
Fig 5.
A: Premature infants born 27 weeks' gestation at his first day of life. Normal tracing for age, note the cycling of the lower border of the aEEG tracing. Different patterns can be depicted in this tracing: Low discontinuous (black stars), high discontinuous (white arrows) and, also, short periods of continuous activity: black arrows. On histology, fetal vascular thrombo-occlusive type lesion was observed and he had a good outcome. B: Premature infants born 27 weeks' gestation at his first day of life. Depressed tracing consisting of burst suppression pattern with a short period of isoelectric pattern (arrow). In his placenta signs of maternal underperfusion, vascular type, were observed. As to his outcome, his Bayley's screening assessment classified him at risk and the Amiel-Tison neurological exam scored moderately abnormal.