Table 1.
1000 Genomes Project LCL samples used in this study.
Fig 1.
Distribution of EBV copy number across LCL samples.
Boxplot showing the distribution of EBV copy number in LCLs across 1000 Genome Project populations. (Population acronyms are explained in Table 1).
Fig 2.
Validation of in silico EBV copy number estimation and EBV stability over time.
Correlation between EBV copy number for 13 LCL samples as determined by real-time PCR (X-axis) and in-silico (Y-axis) (A). Relative real-time PCR measurements of EBV copy number in 7 LCLs (shown with different colors) cultured for 6 passages. Viral copy number tends to be stable within one LCL when compared to inter-strain variation (B).
Fig 3.
Manhattan plots for Asian, African American and European population subsets showing top hits from each continent. The blue line indicates p-value of 10−5 and red line indicates p-value of 10−8.
Fig 4.
Regional association plot for Asian (A), European (B), American (C) and African population (D) subsets produced by Locuszoom showing top SNPs from each population subset (in purple) and surrounding SNPs in the region colored by LD (r2) with the top SNP. Lower panel shows genes annotated within this region. Solid blue lines represent recombination rates.
Table 2.
Top EBV copy number-associated regions in the different population subsets.