Fig 1.
Concordance for major diagnostic categories of appendiceal lesions.
Greyed boxes indicate concordant diagnoses between the originating pathologist and academic pathologist. AdCA indicates adenocarcinoma; LAMN, low-grade appendiceal mucinous neoplasm.
Fig 2.
Examples of discordant simple non-neoplastic mucocele cases.
A and B, Appendiceal cross sections with concentric mucosal atrophy and architectural changes of the crypts. C, While decreased, the crypts are focally present within the lamina propria and no cytologic atypia is seen. D, Appendiceal cross section with crypt architectural changes indicating prior mucosal damage. E and F, Appendiceal tip with architectural changes and evidence of prior rupture, including transmural fibrosis and extra-appendiceal mucin. (hematoxylin& eosin, original magnifications x20 [A], x40x [B], 200x [C], 40x [D], 20x [E], and 40x [F]).
Fig 3.
Examples of low-grade appendiceal mucinous neoplasms (LAMN) and adenocarcinoma.
A, Appendiceal base with LAMN and acellular mucin. B, Cytologic atypia seen in LAMN with subjacent abnormal fibrotic stroma without intact lamina propria. C, Florid case of LAMN. D, Cytologic atypia seen in LAMN with undulating and flat profiles and abnormal underlying stroma. E, Invasive adenocarcinoma arising from LAMN and penetrating smooth muscle of the muscularis propria. F, Invasive mucinous adenocarcinoma arising from LAMN with invasion of the smooth muscle layers seen in the bottom left portion of the micrograph. G, LAMN. H, LAMN with abnormal stroma lacking an intact lamina propria. I, Peritoneal extension of LAMN which resembles the luminal neoplasm and includes a hyalinized stroma. (hematoxylin& eosin, original magnifications x40 [A], x200 [B], x40 [C], x200 [D], x400 [E], x400 [F], x200 [G], x200 [H], and x200 [I]).
Table 1.
Proposed checklist for appendiceal neoplasia.