Fig 1.
Representative picture of CXCL1 expression and CXCR2 expression in gastric cancer tissue.
CXCL1 was expressed in cytoplasm in gastric cancer cells (B). CXCR2 was expressed on the membrane in stromal cells (D).
Table 1.
Correlation between the expression of CXCL1 in cancer cells and that of CXCR2 in stromal cells and clinicopathologic features in 270 patients with gastric carcinoma.
Fig 2.
Overall survival of gastric cancer patients based on CXCL1 expression in gastric cancer cells.
A: The Kaplan-Meier survival curve indicated that the overall survival of all patients with CXCL1-positive expression in cancer cells was significantly worse than that of the patients with CXCL1-negative expression (p<0.001). B–E: The Kaplan-Meier survival curve for each stage. Among only the patients at stage I, the patients with CXCL1-positive expression had poorer prognoses than those without CXCL1 expression.
Fig 3.
Overall survival of gastric cancer patients based on CXCR2 expression in stromal cells.
A: The Kaplan-Meier survival curve indicated that the overall survival of all patients with CXCR2-positive expression in stromal cells was significantly worse than that of the patients with CXCR2-negative expression (p<0.001). B–E: The Kaplan-Meier survival curve for each stage. CXCR2 expression could not predict the prognosis of gastric cancer patients for each stage.
Fig 4.
Overall survival of gastric cancer patients based on a combination of CXCL1 in cancer cells and CXCR2 in stromal cells.
A: The Kaplan-Meier survival curve indicated that the overall survival of all patients with both CXCL1 and CXCR2 expressions was significantly worst among those of the patients with either negative or both negative expressions. B–E: The Kaplan-Meier survival curve for each stage. The patients with both expressions of CXCL1 in cancer cells and CXCR2 in stromal cells had significantly worse prognoses than those with either or both negative expressions in stage I.
Table 2.
Univariate and multivariate Cox multiple regression analysis with respect to overall survival after surgery in 270 patients with gastric carcinoma.
Fig 5.
Effect of diffuse-type gastric cancer cells on CXCR2 expression of BM-MCs.
Conditioned medium from diffuse-type gastric cancer cells significantly stimulated the CXCR2 expression in BM-MCs (p<0.01). Data are the mean and SD (error bars) of at least three experiments.