Table 1.
Ratios and formulas derived from (transpulmonary) thermodilution and pulse contour analysis.
Table 2.
Fig 1.
1A-1F: Bland Altman plots comparing (1A) pulmonary vascular permeability index PVPI_fem_uncor derived from femoral injection without activating of a potential correction by the device to the gold standard measurement PVPI_jug using a jugular CVC for indicator injection, (1B) pulmonary vascular permeability index PVPI_fem_cor derived from femoral injection after activiation of a potential correction by the device to the gold standard measurement PVPI_jug using a jugular CVC for indicator injection, (1C) pulmonary vascular permeability index PVPI derived from femoral indicator injection with (PVPI_fem_cor) and without (PVPI_fem_uncor) activation of a potential correction by the device, (1D) pulmonary vascular permeability index PVPI derived jugular indicator injection PVPI_jug to PVPI-fem_uncor_form which was derived from femoral indicator injection without activation of a potential correction by the device, but correction based on the formula suggested for correction of femoral indicator injection derived GEDVI: GEDVIcorrected [mL / m2] = 0.539 * GEDVIuncorrected—15.17 + 24.49 * CIuncorrected 2.311* BWideal. PVPI_fem_uncor_form was calculated by multiplying PVPI_fem_uncor with the ratio 0.25*GEDVuncorrected/0.25*GEDVcorrected, (1E) global ejection fraction GEF_fem_uncor derived from femoral injection without activating of a potential correction by the device to the gold standard measurement GEF_jug using a jugular CVC for indicator injection, (1F) global ejection fraction GEF_fem_cor derived from femoral injection after activiation of a potential correction by the device to the gold standard measurement GEF_jug using a jugular CVC for indicator injection, (1G) global ejection fraction GEF derived from femoral indicator injection with (GEF_fem_cor) and without (GEF_fem_uncor) activation of a potential correction by the device.
Table 3.
Measurements of pulmonary permeability index PVPI_fem_uncor and PVPI_jug categorized “PVPI ≥3”, “1<PVP<3” and “PVPI≤1”.
Measurements classified in the same category are depicted in bold letters.
Fig 2.
Algorithm for the calculation of GEDV, GEDVI, PBV, PVPI and GEF as displayed by the PiCCO-2 software V 3.1.
Confounders (volume of VCI) and confounded values with marked deviation from corresponding measurements using jugular access (PBV, PVPI_fem) are shaded. The primarily measured GEDVfem_uncor is indexed to predicted body surface area (BSA) resulting in GEDVI_fem_uncor. In a next step GEDVI_fem_cor is derived from correction of GEDVI_fem_uncor according to the previously suggested formula. Unindexed GEDV_fem_cor results from multiplication of GEDVI_fem_cor by predicted BSA and is used for calculation of GEF_fem_cor. By contrast, PVPI_fem is based on GEDV_fem_uncor irrespective of giving the information about the femoral CVC-position.
GEDV(I): global end-diastolic volume (index)
PBV: pulmonary blood volume
PVPI: pulmonary vascular permeability index
GEF: global ejection fraction
BSA: body surface area
Fig 3.
Algorithm assumed for the calculation of GEDV, GEDVI, PBV, PVPI and GEF as displayed by the EV-1000 [5].
Confounders (volume of VCI) and confounded values with marked deviation deviation from corresponding measurements using jugular access (PBV, PVPI_fem) are shaded. The EV-1000 does not correct any parameter derived from femoral CVC indicator injection.
GEDV(I): global end-diastolic volume (index)
PBV: pulmonary blood volume
PVPI: pulmonary vascular permeability index
GEF: global ejection fraction