Table 1.
Number of identified instrumental SNPs for metabolic factors, phenotype distribution in the discovery sample, and proportion of phenotype variance explained by the instruments.
SD: standard deviation.
Fig 1.
Forest plot of lung cancer overall risk for one standard deviation (Table 1) increase in each phenotype provided by the MR likelihood-based approach.
CI: Confidence interval. P: P value.
Fig 2.
Forest plot of lung cancer risk for each SD increase in BMI (approximately 4.6 kg/m2) observed in the likelihood-based MR approach.
95%CI: 95% Confidence Interval; P: P value. I2: between-strata heterogeneity. PHet: P value of between-strata heterogeneity.
Fig 3.
Funnel plots for the distribution of risk estimates of BMI instrumental SNPs along with MR causal effect lung cancer subtypes.
OR: Odds ratio; Int: Intercept; P: P value.
Fig 4.
Forest plot of lung cancer risk for each SD increase in LDL (approximately 38.0 mg/dl) observed in the likelihood-based MR approach using the instrument set of common SNPs.
95%CI: 95% Confidence Interval; P: P value. I2: between-strata heterogeneity. PHet: P value of between-strata heterogeneity.
Fig 5.
Forest plot of lung cancer risk for each SD increase in fasting insulin (approximately 44.4 pmol/L) observed in the likelihood-based MR approach.
95%CI: 95% Confidence Interval; P: P value. I2: between-strata heterogeneity. PHet: P value of between-strata heterogeneity.