Table 1.
Demographic and clinical characteristics of participants.
Fig 1.
Multimodal characteristics of the amygdala, OMPFC, hippocampus, insula, and thalamus assessed at each time point.
A set of candidate brain structural features was derived from multimodal neuroimaging data analysis, which comprehensively characterized local, region-wise connectivity, pair-wise connectivity, and network features of the amygdala, orbitofrontal and ventromedial prefrontal cortex (OMPFC), hippocampus, insula, and thalamus.
Fig 2.
The relationships between candidate brain structural features and the group membership at each time point.
The graph presents point-biserial correlation coefficients (r) between candidate features and the group membership at (A) time 1, (B) time 2, and (C) time 3 assessments. Error bars represent standard errors, which were calculated using 5,000 bootstraps. Asterisks in each graph indicate the first 10 brain structural features based on the rank of the absolute r values. Amy, amygdala; OMPFC, orbitofrontal and ventromedial prefrontal cortex; Hippo, hippocampus; Thal, thalamus.
Fig 3.
Multimodal brain structural features and their contribution to the classification of the trauma-exposed group from the trauma-unexposed group at each time point.
(A) Receiver operating characteristic curves of classification models at each time point are presented. Performance of each model for classifying the trauma-exposed group from the trauma-unexposed group as a function of the subset of candidate features was measured using the AUC. The model showing the best classification performance at each time point is plotted in orange color. (B) The best subset of multimodal features for classifying the trauma-exposed group from the trauma-unexposed group at each time point is presented. Classification performance measured using the AUC for individual features is plotted in radar graphs. AUC, area under a receiver operating characteristic curve; Amy, amygdala; OMPFC, orbitofrontal and ventromedial prefrontal cortex; Hippo, hippocampus; Thal, thalamus.
Table 2.
Classification accuracy of individual brain structural features included in the best model for distinguishing trauma-exposed individuals from trauma-unexposed individuals at time 1, 2, and 3.