Fig 1.
Representative Spectralis SD-OCT scans with macular thickness map (ETDRS grid).
C1: the central fovea subfield/sector; S3, I3, T3, N3: superior, inferior, temporal, and nasal sectors, respectively, of the inner circle subfield between 1 and 3 mm; S6, I6, T6, N6: superior, inferior, temporal, and nasal sectors, respectively, of the outer circle subfield between 3 and 6 mm.
Fig 2.
Representation of intra-retinal layer segmentation and thickness measurement.
(A): Segmentation of the retinal boundaries in a normal eye by Spectralis SD-OCT: 1 = inner limiting membrane (ILM); 2 = retinal nerve fiber layer (RNFL); 3 = ganglion cell layer (GCL); 4 = inner plexiform layer (IPL); 5 = inner nuclear layer (INL); 6 = outer plexiform layer (OPL); 7 = outer limiting membrane (OLM); 8 = myoid zone of the photoreceptor layer (PR1); 9 = ellipsoid component of the photoreceptor layer (PR2); 10 = retinal pigment epithelium (RPE); and 11 = Bruch’s membrane. (B): Representative 9 intra-retinal layer measurements within a standard ETDRS grid: average volume and thickness measurements for the fovea subfield, inner and outer circle subfields and 9 sectors.
Table 1.
Demographic and clinical characteristics of the study participants.
Table 2.
RNFL, GCL, IPL, and GCIPL volumes and thicknesses in ETDRS grid for each group.
Table 3.
INL, OPL, ONL, and IRL volumes and thicknesses in ETDRS grid for each group.
Table 4.
PR, RPE, ORL, and TR volumes and thicknesses in ETDRS grid for each group.
Fig 3.
Intra-retinal layer volume and 3 subfields of ETDRS grid thicknesses.
The character “*” indicates significant differences among the groups using ANOVA (P < 0.05). Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), ganglion cell and inner plexiform layer (GCIPL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor layer (PR), retinal pigment epithelium (RPE), inner retinal layer (IRL) and outer retinal layer (ORL).
Table 5.
Correlations and predictors of IPL, GCIPL, OPL thickness (linear regression).
Fig 4.
A-H. Scatterplots for simple linear regression between the mean IPL thickness and age (A), the duration of diabetes (B), the mean RNFL thickness (C), the mean GCL thickness (D), the mean INL thickness (E), the mean OPL thickness (F), the mean IRL thickness (G), and the mean TR thickness (H).