Fig 1.
Flow diagram of screening for participants in this study.
The crude number of patients with microscopic polyangiitis was counted on the basis of ICD-10 codes from medical records in our hospital. Each of the patients was diagnosed with MPA based on the CHCC2012 criteria. Drug-induced and recurrent cases were excluded. Abbreviations: ICD, international classification of diseases; RPGN, rapidly progressive glomerulonephritis; GPA, granulomatosis with polyangiitis; EGPA, eosinophilic granulomatosis with polyangiitis, CHCC; Chapel Hill Consensus Conference, MPA; microscopic polyangiitis.
Table 1.
Baseline characteristics of 43 MPA patients in this study.
Fig 2.
Change in the annual incidence of microscopic polyangiitis (MPA) in the Ishinomaki medical area.
The incident cases were divided by the population at risk in the restricted medical area and plotted according to annual intervals. The white and black bars represent the incidence per 1 million people before and after the disaster, respectively. The mean incidence of MPA was 17.4 /million/year [95% Confidence Interval (CI): 7.66 to 39.61] before the disaster and 33.1 /million/year [95% CI: 17.73 to 61.74] after the disaster. The dashed line indicates the mean annual incidence of MPA in Japan. The incidence ratio and P-value were obtained using Poisson regression analysis (P = 0.044).
Table 2.
Comparison of factors before and after the GEJE.
Fig 3.
Comparison of overall survival between before and after the disaster.
Survival curves were plotted to compare the mortality of each group using the Kaplan-Meier method. The dotted and solid lines indicate the time-to-events of participants before and after the disaster, respectively. The notches within the line represent the censors. The numbers at risk are illustrated below the chart. Overall survival was significantly worse in the group after the disaster (P = 0.029 by log rank test).