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Table 1.

Costs and valuation per category.

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Table 1 Expand

Fig 1.

CONSORT flow diagram.

CFS = chronic fatigue syndrome, CIS = Checklist Individual Strength, MRT = Multidisciplinary rehabilitation treatment, CBT = Cognitive behavioural therapy, BMI = Body Mass Index, TiC-P = Trimbos/iMTA questionnaire for Costs associated with Psychiatric Illness.

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Fig 1 Expand

Table 2.

Baseline characteristics (N = 109).

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Table 2 Expand

Table 3.

Estimated effect of MRT versus CBT.

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Table 3 Expand

Table 4.

Mean costs (in €).

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Table 4 Expand

Fig 2.

Acceptability curves of the cost-effectiveness (outcome CIS fatigue and SF-36) at 52 weeks follow-up.

SA = Sensitivity analysis, CEA = Cost-effectiveness analysis, CIS = Checklist Individual Strength, SF-36 = Short-form 36, PCS = Physical component summary score, MCS = Mental component summary score.

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Fig 2 Expand

Fig 3.

Acceptability curves of cost-utility (QALY) at 52 weeks follow-up.

SA = Sensitivity analysis, CUA = Cost-utility analysis, QALY = Quality-adjusted life-year.

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Fig 3 Expand

Fig 4.

Cost-effectiveness plane (primary outcome: CIS fatigue).

CIS = Checklist Individual Strength.

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Fig 4 Expand

Fig 5.

Cost-utility plane (primary outcome: QALY).

QALY = Quality-adjusted life-year.

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Fig 5 Expand

Table 5.

Mean total costs and group differences at 52 weeks after baseline (N = 109).

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Table 5 Expand

Fig 6.

Acceptability curves (sensitivity analysis) of cost-effectiveness (outcome improvement on CIS and EET) at 52 weeks follow-up.

SA4 = Sensitivity analysis 4, EET = Improvement and satisfaction questionnaire, question 4 “Is there a difference in your daily activities now, CIS = Checklist Individual Strength.

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Fig 6 Expand