Fig 1.
NQO1 expression correlates with 17-AAG effectiveness in multiple cancer types.
Green color represents negative Spearman’s rank correlation coefficients between NQO1expression and 17-AAG EC50 in the CCLE (A) and IC50 (EC50 was not available) in GDSC (B). These results indicate that 17-AAG works better when NQO1 expression is higher. Only p < 0.05 correlations are shown.
Fig 2.
VEGFA expression correlates with drug sensitivity.
Green and red colors represent negative and positive Spearman’s rank correlation coefficients between VEGFA levels and different anticancer drugs’ IC50 in the CCLE (A) and GDSC (B). A positive correlation with IC50 means that the drug is less effective; a negative correlation indicates that it is more effective when VEGFA expression is higher. p < 0.05 correlations are displayed.