Table 1.
Description of the 23 extracted factors describing facial morphology.
Fig 1.
Phenotype and association results for facial factor 9.
(A) Face showing the linear distances (in dark yellow) associated with factor 9; (B) LocusZoom plot showing the association (left y-axis; log10-transformed p-values) with factor 9. Genotyped SNPs are depicted by stars and imputed SNPs are depicted by circles. Shading of the points represents the linkage disequilibrium (r2, based on the 1000 Genomes Project Europeans; gray indicates unknown LD) between each SNP and the top SNP, indicated by purple shading. The blue overlay shows the recombination rate (right y-axis). Positions of genes are shown below the plot. Note, gray points near the lead SNP are insertion-deletion variants in high LD (r2 = 0.91 and 0.77) with the lead SNP in our cohort.
Fig 2.
Phenotype and association results for facial factor 17.
(A) Face showing the linear distances (in light green) associated with factor 17; (B) LocusZoom plot showing the association (left y-axis; log10-transformed p-values) with factor 17. Genotyped SNPs are depicted by stars and imputed SNPs are depicted by circles. Shading of the points represents the linkage disequilibrium (r2, based on the 1000 Genomes Project Europeans; gray indicates unknown LD) between each SNP and the top SNP, indicated by purple shading. The blue overlay shows the recombination rate (right y-axis). Positions of genes are shown below the plot. Note, the gray point near the lead SNP is an insertion-deletion variant in high LD (r2 = 0.82) with the lead SNP in our cohort.
Fig 3.
Phenotype and association results for facial factor 14.
(A) Face showing the linear distances (in red) associated with factor 14; (B) LocusZoom plot showing the association (left y-axis; log10-transformed p-values) with factor 14. Genotyped SNPs are depicted by stars and imputed SNPs are depicted by circles. Shading of the points represents the linkage disequilibrium (r2, based on the 1000 Genomes Project Europeans; gray indicates unknown LD) between each SNP and the top SNP, indicated by purple shading. The blue overlay shows the recombination rate (right y-axis). Positions of genes are shown below the plot. Note, the gray point near the lead SNP is an insertion-deletion variant in high LD (r2 = 0.97) with the lead SNP in our cohort.
Table 2.
Genome-wide significant results for seven facial factors.