Fig 1.
Representative OCTA images of fellow healthy eye and BRVO eye illustrating qualitative changes in capillary density and morphology.
(A) B-scan with purple dotted lines delineating the retinal vascular layers of interest in the healthy fellow eye of an RVO subject: Nonsegmented whole retina, NS-RL (a-d); Superficial retina layer, SRL (a-b); Deeper retina layer, DRL (b-c). Corresponding pseudocolored, depth-encoded OCTA map (B), binarized image (C), and skeletonized image (D) of the unaffected eye. (E-H) Corresponding images of the RVO eye, NS-RL analysis.
Table 1.
Characteristics of patients with retinal venous occlusion and control subjects.
Fig 2.
Comparison of quantitative OCTA parameters between RVO eyes and control eyes for nonsegmented layer analysis.
Row (A) bar charts illustrate the mean±SD of the quantitative OCTA parameters (Fractal Dimension, Vessel Density, Skeletal Density and Vessel Diameter Index) for eyes with retinal venous occlusion (RVO), the unaffected fellow eye (OE), and control eyes. Row (B) illustrates the same quantitative parameters for central (CRVO) and branch RVO (BRVO) compared to controls. Row (C) illustrates similarly for RVO eyes with and without macular edema. Multivariable linear regressions were performed and the GEE approach was used to control for age, gender, and between-eye correlation when appropriate. The asterisk(s) above the horizontal line indicates that the specified groups were statistically different. All other asterisks compare specified groups to controls. One asterisk, p<0.05; two asterisks, p<0.01; three asterisks, p<0.001.
Table 2.
Comparison of quantitative OCTA parameters of BRVO and CRVO eyes compared to controls.
Fig 3.
Magnitude and direction of change in quantitative OCTA parameters among all study subjects using nonsegmented layer analysis.
Linear regression slope coefficient (β) indicating magnitude and direction of parameter difference, and corresponding confidence intervals. Abbreviations: RVO, retinal venous occlusion, OE, other (unaffected fellow) eye; CRVO, central retinal venous.