Fig 1.
Measurement of the signaling entropy in GSE63514.
The entropy rate was significantly higher according to the disease progression (Kruskal-Wallis test, p < 0.0001). Cancer; invasive cancer.
Fig 2.
Measurement of the signaling entropy in GSE27678.
(A) Boxplot of the entropy rate from whole samples. The entropy rate increased according to the disease progression (Kruskal-Wallis test, p < 0. 001). Among them, the entropy rate from the cell line was highest, as described in the literature [9]. (B) Entropy rate from each platform. ○ represents the data obtained from the Affymetrix Human Genome U133A 2.0 Array, and * represents the data obtained from the Affymetrix Human Genome U133 Plus 2.0 Array. The distribution patterns of the entropy rate seemed slightly different among the platforms.
Fig 3.
Measurement of the signaling entropy in GSE75132.
The median of the entropy rate was higher in the HPV16-persistent (HPV16+) groups than the HPV-negative (HPV-) group. The group that was destined to progress to CIN3+, or the HPV16-persistent with progression group, tended to have a higher entropy rate than the HPV16-persistent without progression group.