Fig 1.
Flow diagram of included ICUs and patients in 2007 and 2014.
+ Some ICUs that contributed data to both studies may have been defined as a single ICU in one study but as two ICUs in another study therefore the ‘paired’ ICU number not half of the total ICU number. These ICUs were combined into one ICU (as appropriate) to enable comparison of fluid use over time.
Table 1.
Countries, intensive care units, patients, and fluid resuscitation episodes.
Fig 2.
Proportion of all fluid resuscitation episodes of crystalloid and colloid in 2014 in 426 ICUs.
Proportions may not add to 100% as patients can be administered more than one type of fluid during resuscitation episodes. Denominator for crystalloid and colloid panel is all fluid resuscitation episodes (n = 2716); Denominator for crystalloid panel is for all crystalloid episodes (n = 2208); Denominator for colloid panel is for all colloid episodes (n = 581). BSS = Buffered Salt Solutions. HES = Hydroxyethyl Starch. Other = other crystalloids.
Table 2.
Countries, intensive care units, and patients included in comparison between 2007 and 2014.
Fig 3.
Proportion of all fluid resuscitation episodes given in 2007 and 2014 in 84 ICUs.
Denominator for crystalloid and colloid panel is all fluid resuscitation episodes (n = 1167 in 2007 and n = 960 in 2014); Denominator for crystalloid panel is for crystalloid episodes only (n = 498 in 2007 and n = 694 in 2014); Denominator for colloid panel is for all colloid episodes (n = 724 in 2007 and n = 297 in 2014). Proportions may not add to 100% as patients can be administered more than one type of fluid during resuscitation episodes. BSS = Buffered Salt Solutions. HES = Hydroxyethyl Starch. Other = other crystalloids.
Fig 4.
Forest plots of change in use of crystalloid fluid resuscitation episodes between 2007 and 2014; overall and by pre-defined subgroup.
Unadjusted odds ratios and 95% Confidence Intervals (CI) presented.
Table 3.
Results of multivariate and sensitivity analysis for receiving crystalloid and colloid fluid resuscitation episodes in 2014 compared to 2007.
Fig 5.
Forest plots of crystalloid fluid resuscitation episodes between 2007 and 2014; overall and by region subgroup.
Unadjusted odds ratios and 95% Confidence Intervals (CI) presented.