Table 1.
CT acquisition and image reconstruction parameters.
Table 2.
Baseline demographics, clinical characteristics, and CACS of LCSCT vs. ACCT populations.
Fig 1.
Scatter plot of Agatston CACS from CCT scans and either LCSCT or ACCT scans along with corresponding Bland-Altman plots for agreement.
(A) The Pearson correlation of CACS between CCT scans and LCSCT scans. (B) Bland-Altman Plots for Agreement between CCT scans and LCSCT scans. (C) The Pearson correlation of global CACS between CCT scans and ACCT scans. (D) Bland-Altman Plots for Agreement between CCT scans and ACCT scans.
Table 3.
Comparison of the Pearson correlation of total CACS and individual vessel CACS between LCSCT and ACCT.
Fig 2.
Example of the decreased detection of calcium using ACCT relative to CCT and LCSCT in a single slice plane of the LAD from an individual patient.
CCT with LAD Agatston CACS of 645. LCSCT with LAD Agatston CACS of 749. ACCT with LAD Agatston CACS of 203. Bar, 3cm. Upper panel; CT images at the level of the proximal to mid LAD. Red arrow; identified calcium. Yellow arrow; unidentified calcium. Lower panels; CT images as displayed at the imaging workstation with pixels of Agatston threshold of 130 Hounsfield units (HU) highlighted in red and region of interest circled in yellow. In this example, LCSCT images were acquired 14 months after the CCT images and the ACCT images were acquired 3 months prior to the CCT images.
Fig 3.
Receiver operator characteristic curves for CCT, LCSCT, and ACCT.
(A) ROC curve for CCT with AUC of 0.8302 (P = 0.0004). (B) ROC curve for LCSCT with AUC of 0.8133 (P = 0.0007). (C) ROC curve for ACCT with AUC of 0.7969 (P = 0.01).
Fig 4.
Kaplan-Meier event curve for MACE using (A) CCT, (B) LCSCT, and (C) ACCT in patients divided into low and high calcium burden as determined by their respective ROC Curves (**, P < 0.01, log-rank test).