Table 1.
Treatment outcome definitions (adapted from the AASLD practice guidelines for Hepatitis C) and screening criteria for Hepatitis C risk factors in a primary health care-based program for management of chronic Hepatitis C, Karachi, Pakistan.
Table 2.
Conditions for treatment ineligibility and treatment deferral in a primary health care-based program for management of chronic Hepatitis C, Karachi, Pakistan.
Table 3.
Sociodemographic and characteristics of chronic Hepatitis C patients enrolled in a primary health care-based program for management of chronic Hepatitis C, Karachi, Pakistan; February to December 2015.
Fig 1.
Flowchart for diagnosis and treatment prioritization among CHC patients in a primary health care-based program for management of chronic Hepatitis C, Karachi, Pakistan; February to December 2015.
1 Initial clinical assessment rules out patients with known medical conditions contraindicated for treatment initiation such as decompensated cirrhosis, hematologic diseases, severe renal insufficency. 2Aspartate aminotransferase (AST) to Platelet Ratio Index 3Patients with low APRI scores (0.1–0.49), with co-infection (TB, HIV, and Hepatitis B), Pregnancy and Lactation 4Patients with APRI score 0.5–0.99 5Patients with APRI above 1.0
Table 4.
Characteristics of patients in the priority list for Hepatitis C treatment and risk factors for delayed start of treatment in a primary health care-based program for management of chronic Hepatitis C, Karachi, Pakistan; February to December 2015.
Fig 2.
Flowchart for treatment among chronic Hepatitis C patients in a primary health care-based program for management of chronic Hepatitis C, Karachi, Pakistan; February to December 2015.
1 Sofosbuvir 400mg/day + weight-based Ribavirin 800–1200 mg/day + Pegylated interferon 180 μg/week Subcutaneous for 12 weeks 2 Sofosbuvir 400 mg/day +weight based Ribavirin 800–1200 mg/day 3 Sustained virological response (cure)
Fig 3.
Percentage of chronic Hepatitis C patients who developed anemia while on treatment in a primary health care-based program for management of chronic Hepatitis C, Karachi, Pakistan; February to December 2015.
1 WHO. Hemoglobin concentrations for the diagnosis of anemia and assessment of severity.