Fig 1.
Gene-set enrichment analyses of differentially expressed genes between normal breast and basal like breast cancer, and association with clinical outcome.
A. Overexpressed genes with a minimum of two fold-change difference between normal breast and basal-like breast cancer (left side), as described in material and methods. Using functional annotation, only genes associated with functions linked with cell membrane proteins were included (right side). B. Identification of immunologic related genes included in the identified functions (16 genes). Selection of genes which upregulation was confirmed using data contained at Oncomine (10 genes) and linked with outcome. Outcome screening analyses for RFS and OS using the KMplotter online tool for those ten identified genes.
Table 1.
List of the identified immunologic-related genes associated with RFS and OS in basal like breast cancer.
Table 2.
List of gene combinations associated with favorable outcome in basal like cancer using the KM plotter online tool, as described in material and methods.
Fig 2.
Association of the combined analyses of HLA-F and TIGIT with RFS and OS in basal-like patients using the KM plotter online tool, as described in material and methods.
Fig 3.
Association of the combined analyses of HLA-F, HLA-C and TIGIT with RFS and OS in basal-like patients using the KM plotter online tool, as described in material and methods.
Fig 4.
A. Association of the combined analyses of HLA-F and HLA-C with OS by using data available in METABRIC. B. Association of the combined analyses of HLA-F and HLA-C with RFS by using data available in GSE25066.