Table 1.
Sample sizes.
Table 2.
Interactions with physical activity.
Table 3.
Interactions with artificially sweetened beverages.
Table 4.
Interactions with pack years.
Fig 1.
Over-all effects of FTO and MC4R with 95% confidence intervals, for men and women in three age groups. Asterisk indicates FDR-adjusted p-value below 0.05 for testing H0: βSNP = 0 against H1: βSNP ≠ 0.
Fig 2.
Longitudinal effects of FTO and MC4R with 95% confidence intervals, for men and women in three age groups (30–40 years as youngest age group because individuals younger than 30 years in HUNT3 did not participate in HUNT2). Asterisk indicates FDR-adjusted p-value below 0.05 for testing H0: βSNP = 0 against H: βSNP ≠ 0.
Fig 3.
Gene-environment interaction effects.
Estimated WHR (a) and BMI (b) in the 20–40 years age group for all FTO genotypes and for increasing levels of physical activity (PA) for an average man (age 31, ASB 4.2, PCYR 1.8) and woman (age 31, ASB 4.7, PCYR 2.1). Estimated BMI in the 40–60 years age group for all FTO genotypes for increasing levels of intake of artificially sweetened beverages (c) and increasing number of pack years (d) for an average man (age 51, PA 4.2, ASB 2.7, PCYR 7.4) and woman (age 49, PA 4.3, ASB 2.7, PCYR 7.1).