Table 1.
Socio-demographic and clinico-pathologic parameters of the 75 OSCC cases involved in array CGH study.
Fig 1.
The ideogram of amplifications and deletions identified in this study using array CGH.
Fig 2.
The ideogram of CNAs identified representing intersection of cytoband CNAs from TCGA and ICGC studies.
Table 2.
Amplified and deleted regions detected in 75 OSCC samples.
Table 3.
Association of chromosomes 7p, 8q, 9p, 11q, 8p and the combination of chromosomes 7p, 8q, 9p, 11q with clinico-pathologic parameters in OSCC.
Fig 3.
Overall survival curves were analyzed according to amplification of chromosome 7p, 8q, 9p, 11q and deletion of chromosome 8p and ≥ 1 of chromosome 7p, 8q, 9p and 11q using Kaplan-Meier estimate with log-rank test.
Fig 4.
Concordance percentage for amplification of LRP12 (chr 8q), CCND1 (chr 11q), TPM2 (chr 9p), FSCN1 (chr 7p), EGFR (chr 7p), CLPTM1L (chr 5p) and deletion of CHL1 (chr 3p) and CSMD1 (chr 8p) identified using array CGH and validated using qPCR copy number analysis in OSCC samples.
Fig 5.
Overall survival curves were analyzed according to ≥ 1 of genetic marker (EGFR, CCND1, TPM2 and LRP12) using Kaplan-Meier estimate with log-rank test.
Table 4.
Multivariate cox regression model analysis of four combined genetic markers consisting of EGFR, TPM2, CCND1 and LRP12 in OSCC overall survival.
Table 5.
Top significant pathways associated with CNAs associated genes.
Table 6.
Top significant molecular and cellular functions associated with CNAs involving associated genes.
Table 7.
Top significant networks and the associated network functions linked with CNAs associated genes.