Fig 1.
Relative abundance distribution of the 66 OTUs whose mean relative abundances in the pre-therapy samples from any of 4 niches exceeded 1%.
The relative abundances of each OTU were normalized to a mean of 0 with standard deviation of 1 (z-score normalization) and are represented by the blue gradient in each grid (light = low abundance; dark = high abundance). The OTUs were ordered based on the result of a hierarchical cluster analysis using the Bray-Curtis distance, which is depicted as a dendrogram on the left side of the diagram. The 12 OTUs belonging to cluster III were characteristically more predominant in SUBP as compared to microbiota from the other three niches. It is displayed in the box with a broken line. Oral taxon IDs were given in parentheses following bacterial names.
Table 1.
Correlation of the relative abundance of each SUBP-specific OTU in SL and the percentage of sites with periodontal pockets (≥4 mm depth).
Fig 2.
Total relative abundances of the 12 SUBP-specific OTUs in the pre-therapy samples from each niche.
The mean relative abundance in each niche is represented by a line and a number.
Fig 3.
Correlation of the total relative abundance of the 12 SUBP-specific OTUs in SL and SUBP samples, or the percentage of sites with periodontal pockets (≥4 mm depth).
The Pearson correlation coefficient (r) and the P value are shown in the upper or upper left side of the diagram. The gray line depicts the regression line.
Fig 4.
Correlation of total relative abundance shift of the 12 SUBP-specific OTUs in SUBP samples with that in SL samples following periodontal therapy.
The Pearson correlation coefficient (r) and the P value are shown in the upper side of the diagram.