Table 1.
Histopathological results.
Fig 1.
Examples of typical cases for each type of score.
(A) A 43-year-old woman with a mucinous carcinoma in the left breast. The rs-EPI DWI demonstrated an oval circumscribed mass with a heterogeneous internal pattern in the left breast, which was scored as 1 (probably benign finding) during qualitative analysis. (B) An 80-year-old woman with invasive ductal carcinoma in the right breast. The rs-EPI DWI demonstrated an oval circumscribed mass with a homogeneous internal pattern in the right breast, which was scored a 1 (probably benign finding) on qualitative analysis. (C) A 61-year-old woman with ductal carcinoma in situ of the left breast. During qualitative analysis of rs-EPI DWI, there was a focal heterogeneous non-mass lesion, which was scored a 2 (indeterminate finding). (D) A 44-year-old woman with invasive ductal carcinoma in the right breast. The rs-EPI DWI demonstrated an irregular mass with an irregular margin and a homogeneous internal pattern, which was scored a 2 (indeterminate finding). (E) A 59-year-old woman with invasive ductal carcinoma of the left breast. During qualitative analysis of rs-EPI DWI, there was a segmental heterogenous non-mass that was scored a 3 (probably malignant finding). (F) A 51-year-old woman with invasive ductal carcinoma of the left breast. During qualitative analysis of rs-EPI DWI, there was an irregular spiculated mass with rim sign, which was scored a 3 (probably malignant finding).
Table 2.
Morphological descriptors used in DWI qualitative analysis according to estimated malignancy risk.
Table 3.
DWI characteristics of 141 lesions for predicting malignancy.
Fig 2.
33-year-old woman with invasive ductal carcinoma in the left breast.
Contrast-enhanced T1-weighted axial image (A), readout-segmented echo-planar DWI image (B), and ADC map (C). (A) Round circumscribed mass with heterogeneous enhancement in the breast. With DWI, at 750 seconds/mm2, there is a round circumscribed mass with heterogeneous high signal intensity in the left breast (B) with low ADC (0.8×10−3 mm2/sec) (C). The patient underwent breast-conserving surgery. The final diagnosis was invasive ductal carcinoma of histological grade III and triple-negative subtype.
Table 4.
Univariate and multivariate logistic regression analysis of DWI characteristics for predicting malignancy.
Table 5.
Distributions of scores for the qualitative DWI analysis and BI-RADS categories of the morphological analysis of DCE-MRI.
Fig 3.
ROC analysis comparing the diagnostic performances of DWI (qualitative alone, quantitative alone, and combination) and DCE-MRI (DCE-MRI alone, DCE-MRI plus ADC).
Table 6.
Comparing the diagnostic performances of DWI and DCE-MRI.
Table 7.
Diagnostic performance of the DWI combination analysis by lesion size.