Fig 1.
Topoisomerase family genes analysis in lung Adenocarcinoma (Ade) and Squamous Cell lung Carcinoma (SCC) (Oncomine database).
Figures were derived from gene expression data in Oncomine comparing expression levels of topoisomerase family genes in normal (left plot) and cancer tissue (right plot) and plotted using Graphpad Prism software. Y-axis represents the median intensity, 10th and 90th percentile data. (A) Comparison of TOP1 mRNA expression in Ade. (B) Comparison of TOP1 mRNA expression in SCC. (C) Comparison of TOP1MT mRNA expression in Ade. (D) Comparison of TOP1MT mRNA expression in SCC. (E) Comparison of TOP2A mRNA expression in Ade. (F) Comparison of TOP2A mRNA expression in SCC. (G) Comparison of TOP3A mRNA expression in Ade.
Fig 2.
The prognostic value of TOP1 expression.
(A) Survival curves were plotted for all NSCLC patients (n = 1726). (B) Survival curves were plotted for Ade patients (n = 591). (C) Survival curves were plotted for SCC patients (n = 492). Data was analyzed using Kaplan-Meier Plotter. Patients with expression above the median are indicated in red line, and patients with expressions below the median in black line. HR means hazard ratio.
Fig 3.
The prognostic value of TOP1MT expression.
(A) Survival curves were plotted for all NSCLC patients (n = 984). (B) Survival curves were plotted for Ade patients (n = 549). (C) Survival curves were plotted for SCC patients (n = 239). Data was analyzed using Kaplan-Meier Plotter. Patients with expression above the median are indicated in red line, and patients with expressions below the median in black line. HR means hazard ratio.
Fig 4.
The prognostic values of TOP2A expression.
(A) Survival curves were plotted for all NSCLC patients (n = 1726). (B) Survival curves were plotted for Ade patients (n = 591). (C) Survival curves were plotted for SCC patients (n = 492). Data was analyzed using Kaplan-Meier Plotter. Patients with expression above the median are indicated in red line, and patients with expressions below the median in black line. HR means hazard ratio.
Fig 5.
The prognostic value of TOP2B expression.
(A) Survival curves were plotted for all NSCLC patients (n = 1726). (B) Survival curves were plotted for Ade patients (n = 591). (C) Survival curves were plotted for SCC patients (n = 492). Data was analyzed using Kaplan-Meier Plotter. Patients with expression above the median are indicated in red line, and patients with expressions below the median in black line. HR means hazard ratio.
Fig 6.
The prognostic value of TOP3A expression.
(A) Survival curves were plotted for all NSCLC patients (n = 1726). (B) Survival curves were plotted for Ade patients (n = 591). (C) Survival curves were plotted for SCC patients (n = 492). Data was analyzed using Kaplan-Meier Plotter. Patients with expression above the median are indicated in red line, and patients with expressions below the median in black line. HR means hazard ratio.
Fig 7.
The prognostic value of TOP3B expression.
(A) Survival curves were plotted for all NSCLC patients (n = 1726). (B) Survival curves were plotted for Ade patients (n = 591). (C) Survival curves were plotted for SCC patients (n = 492). Data was analyzed using Kaplan-Meier Plotter. Patients with expression above the median are indicated in red line, and patients with expressions below the median in black line. HR means hazard ratio.