Table 1.
Baseline information of the SG, AG and GC.
Fig 1.
The mRNA expression of Claudin-11,23 in GC tissues and paired normal mucosa.
The mRNA expression of Claudin-11,23 in 58 cases of GC tissues and paired normal mucosa. The expression status of claudin-11(A) and 23(B) in gastric cancer tissue and its adjacent normal gastric tissue were measured by real-time PCR. The results of real-time PCR showed that the expression levels of claudin-11, 23 were greatly increased in paracancerous normal gastric tissue than in cancerous tissue (0.043, 4.72*10−4).
Fig 2.
The protein expression of Claudin-11,23 in GC tissues and paired normal mucosa.
The protein expression of Claudin-11,23 in 58 cases of GC tissues and paired normal mucosa. The expression level of claudin-11(A) and 23(B) in gastric cancer tissue and its adjacent normal gastric tissue were measured by western blot. The results of western blot indicated that the expression levels of claudin-11, 23 were obviously higher in paracancerous normal gastric tissue than in cancerous tissue (2.75*10−4, 0.012).
Table 2.
Claudin-11,23 expression in SG and AG of adjacent tissue and GC.
Table 3.
Claudin-11,23 expression in SG, AG, GC tissues from different individuals.
Fig 3.
Immunohistochemical staining for Claudin-11,23 expression in SG, AG, GC.
Immunohistochemical staining for Claudin-11,23 expression in 109 cases of SG, 109 cases of AG and 109 cases of GC. The staining of claudin-11, 23 are mainly located in the cytomembraneand cytoplasm. (A) SG with positive Claudin-11 expression; (B) AG with negative Claudin-11 expression;(C) moderately differentiated GC with positive Claudin-11 expression; (D) poorly differentiated GC with negative Claudin-11 expression; (E) SG with positive Claudin-23 expression; (F) AG with negative Claudin-23 expression; (G) moderately differentiated GC with negative Claudin-23 expression;(H) poorly differentiated GC with negative Claudin-23 expression. Magnification, ×200.
Table 4.
Association between Claudin-11,23 expression and clinicopathological parameters in GC.
Table 5.
Association between Claudin-11,23 expression and CEA and GSTP1.
Fig 4.
Correlation of Claudin-11,23 expression with survival curves of gastric cancer patients by univariate survival analysis.
Correlation of Claudin-11, 23 expression with survival curves of gastric cancer patients by univariate survival analysis. (A) Kaplan-Meier survival curves comparing months of survival in gastric cancer patients are shown for Claudin-11 expression (P = 0.863); (B) Kaplan-Meier survival curves comparing months of survival in gastric cancer patients are shown for Claudin-23 expression (P = 0.031).
Table 6.
Correlation between Claudin-11,23 expression and survival in GC.