Table 1.
Medetomidine-midazolam-fentanyl anaesthesia dosage and antagonization for guinea pig anaesthesia.
Fig 1.
Repeated anaesthesia time schedule.
Each GP was anaesthetized 6 times over 3 weeks with either MMF or Iso (in this example, first Iso), followed by a wash-out phase of 10 d. Thereafter the same GP was anaesthetized with the other substance (here MMF) for 6 repetitions. R1 = anaesthesia repetition #1, Iso = Isoflurane, MMF = medetomidine-midazolam-fentanyl.
Table 2.
Daily schedule of repeated anaesthesia with MMF or Iso in GPs.
Fig 2.
Course of one anaesthesia repetition with either MMF or Iso.
* The parameters during the last 15 min of the habituation time were averaged as daily baseline values for that GP.
Table 3.
Anaesthesia phase definition.
Table 4.
MMF and Iso anaesthesia phase durations during guinea pig anaesthesia.
Table 5.
Faster return to the righting reflex in the course of repeated MMF anaesthesia.
Fig 3.
Mean Arterial blood Pressure (MAP) variance during surgical tolerance in male guinea pigs.
Mean arterial blood pressure (MAP) variance during surgical tolerance in 3 group representative male guinea pigs during 6 repeated anaesthesias with medetomidine-midazolam-fentanyl. 1st grey line ≙ premedication at -10min, 2nd line ≙ induction at 0min; 3rd line ≙ antagonization at 40 min.
Table 6.
Return to the righting reflex at lower MAPs in the course of repeated MMF anaesthesia in guinea pigs.
Table 7.
Parameter values over 6 rounds of repeated medetomidine-midazolam-fentanyl anaesthesia in guinea pigs.
Table 8.
Return to the righting reflex at lower heart rates in the course of repeated anaesthesia in guinea pigs.
Table 9.
Parameter values over 6 rounds of repeated isoflurane anaesthesia in guinea pigs.
Fig 4.
Respiratory rate course during repeated anaesthesia in guinea pigs.
Repeated anaesthesias (6 times with an interval of 3 or 4 days) with isoflurane (Iso) and medetomidine-midazolam-fentanyl (MMF) in 12 male guinea pigs.
Table 10.
Variations of blood glucose values during repeated medetomidine-midazolam-fentanyl anaesthesia in guinea pigs.
Fig 5.
Anaesthesia duration in 6 repeated anaesthesias with Iso and MMF male guinea pigs.
Duration of anaesthesia intervals [min] in 6 repeated anaesthesias with isoflurane (Iso) and medetomidine-midazolam-fentanyl (MMF) in 12 male guinea pigs.
Fig 6.
MAP during 6 times repeated anaesthesia with Iso and MMF in guinea pigs.
MAP = Mean arterial blood pressure [mmHg]; isoflurane (Iso) and medetomidine-midazolam-fentanyl (MMF) anaesthesia in 12 male guinea pigs; 1st grey line ≙ premedication at -10min, 2nd line ≙ induction at 0min; 3rd line ≙ antagonization at 40 min.
Fig 7.
Heart rate during 6 times repeated anaesthesia with Iso and MMF in guinea pigs.
Heart rate [bpm] during repeated isoflurane (Iso) and medetomidine-midazolam-fentanyl (MMF) anaesthesia in 12 male guinea pigs; 1st grey line ≙ premedication at -10min, 2nd line ≙ induction at 0min; 3rd line ≙ antagonization at 40 min.
Fig 8.
BT during 6 times repeated anaesthesia with Iso and MMF in guinea pigs.
Core body temperature [°C] during repeated isoflurane (Iso) and medetomidine-midazolam-fentanyl (MMF) anaesthesia in 12 male guinea pigs; 1st grey line ≙ premedication at -10min, 2nd line ≙ induction at 0min; 3rd line ≙ antagonization at 40 min.
Fig 9.
Blood glucose course during 6 times repeated anaesthesia with Iso and MMF in guinea pigs.
Blood samples were taken at 7.5, 20 and 40 min during anaesthesia with isoflurane (Iso) and medetomidine-midazolam-fentanyl (MMF) in 12 male guinea pigs.