Fig 1.
Flow chart indicating different phases of the study.
Men were eligible if they were HIV/STI free, aged ≥18 years, and had adequate English and comprehension to provide written informed consent. Exclusion criteria were any antibiotic use in the previous two weeks, commercial sex work and any current drug use likely to interact or be contraindicated to azithromycin use. Recruitment and intervention took place in a large metropolitan sexual health centre where they were offered a standard STI screen and reimbursed $100 for their time and transport.
Table 1.
Summary of participant demographics, estimated pharmacokinetics parameters, sexual behaviour and concurrent medication use.
Fig 2.
Tissue concentration (mcg/g) over time (hours) by participant*.
*The scale of the y-axis for participant 7 is different from all other participants because their azithromycin levels were considerable higher.
Table 2.
Azithromycin tissue concentration by esomeprazole use (increased gut pH), douching, moderate diarrhoea and water-based lubricant use.
Table 3.
Relative concentrations (mcg/g) by time, dose and tissue type.