Fig 1.
Cases of papillary and follicular thyroid carcinoma with bone metastasis enrolled from the thyroid cancer patient database of the Chang Gung Memorial Hospital.
The clinical staging used was as follows: stage I, tumor confined to the thyroid; stage II, lymph node (LN) metastasis; stage III, soft tissue (ST) involvement; and stage IV, distant metastasis (DM).
Table 1.
Clinical features of papillary or follicular thyroid cancer with bone metastasis in different group.
Fig 2.
Thyroid cancer-specific survival rates for the three groups of patients with bone metastasis.
The disease-specific survival rates for groups A, B, and for all patients included in the study were 53.4%, 85.0%, and 63.5% at 5 years; 22.9%, 64.2%, and 36.7% at 10 years; 9.4%, 37.3%, and 18.2% at 20 years; and 3.7%, 37.3%, and 10.8% at 30 years, respectively. The difference in disease-specific mortality rates between groups A and B was significant difference (p < 0.0001).
Table 2.
Clinical features of papillary or follicular thyroid cancer with bone metastasis in thyroid cancer mortality or non-cancer mortality.
Fig 3.
Multivariate analysis using cox proportional hazards regression model for survival and mortality.