Table 1.
Test characteristics of the screening tests used in the model.
Table 2.
Utility weights used in the model.
Table 3.
Cost estimates used in the model (2013 Canadian dollars).
Fig 1.
Discounted total costs and discounted QALYs gained, per 1,000 participants, of the gFOBT and FIT screening strategies compared to no screening.
QALY: quality adjusted life year; gFOBT: guaiac fecal occult blood test; FIT: fecal immunochemical test. Current screening strategy in Ontario: biennial gFOBT, between age 50–74. Strategies are varied by age at starting screening, age at stopping screening, screening interval, and FIT cut-off level. The cost-effective strategies are connected by the efficient frontier. Costs (expressed in 2013 Canadian dollars) and QALYs are discounted by 3% per year.
Fig 2.
Efficient frontiers for different levels of colonoscopy capacity.
Costs and QALYs gained per 1,000 participants, compared to no screening. QALY: quality adjusted life year; gFOBT: guaiac fecal occult blood test; FIT: fecal immunochemical test; Col/year: number of colonoscopies required per 1,000 participants per year. Strategies are varying by age at starting screening, age at stopping screening, screening interval, and FIT cut-off level. For each level of available colonoscopy capacity (maximal 17, 20, 30, 40 colonoscopies per 1,000 participants per year and unrestricted colonoscopy capacity) the cost-effective strategies are connected by their respective efficient frontier. The text boxes beside each frontier present the screening strategy (test, age range, interval and colonoscopy
Table 4.
Overview of the current gFOBT screening strategy in Ontario, and efficient FIT screening strategies, compared to no screening*.
Outcomes per 1,000 participants.
Table 5.
Undiscounted intermediate model outcomes per 1,000 participants, compared to no screening.