Fig 1.
Images of the right eye in a patient with Vogt-Koyanagi-Harada disease who did not develop sunset glow fundus (SGF) during follow-up (Case 15).
(A, B) Fundus photographs show serous retinal detachment (SRD) extending from the peripapillary area to the posterior pole, choroidal folds, and optic disc swelling before treatment (A) and complete resolution of SRD without onset of SGF at 12 months after the start of systemic corticosteroid therapy (B). (C, D) Horizontal images through the fovea on enhanced depth imaging optical coherence tomography. A pretreatment image demonstrates SRD extending from the optic disc to the macula, bumpy undulation of the retinal pigment epithelium, and marked choroidal thickening. Central choroidal thickness (CCT) was > 800 μm (C). One week after initiation of systemic corticosteroid therapy, the SRD in the vicinity of the disc disappeared and the CCT decreased to 301.0 μm (D).
Fig 2.
Images of the right eye in a patient with Vogt-Koyanagi-Harada disease who developed sunset glow fundus (SGF) during follow-up (Case 4).
(A, B) Fundus photographs show serous retinal detachment (SRD) extending from the disc to the macula and optic disc swelling before treatment (A) and the presence of SGF with disappearance of SRD at 12 months (B). (C, D) Horizontal images through the fovea on enhanced depth imaging optical coherence tomography. An image taken before treatment demonstrates SRD at the posterior pole and marked choroidal thickening. Central choroidal thickness (CCT) was > 800 μm (C). One week after start of systemic corticosteroids, the area of SRD reduced and the CCT also decreased to 418.5 μm (D).
Table 1.
Baseline Characteristics of Patients with VKH Disease with or without SGF.
Table 2.
Post-Treatment Course of Patients with VKH disease with or without SGF.
Fig 3.
Changes in mean central choroidal thickness (CCT) in the sunset glow fundus (SGF) and non-SGF groups before and after systemic corticosteroid therapy.
The mean post-treatment CCT decreased significantly at all examinations in both groups when compared with baseline. Note that the mean CCT at 1 week after starting treatment was significantly higher in the SGF group (518.2 ± 131.6 μm) than in the non-SGF group (414.8 ± 141.6 μm).
Fig 4.
Comparison of central choroidal thickness (CCT) between the sunset glow fundus (SGF) and non-SGF groups at 1 week after starting treatment.
There was a significant difference in the thick:thin ratio with a cut-off value of 410 μm for CCT between the SGF (9:0 eyes) and non-SGF (13:17 eyes) groups at 1 week after starting treatment (P = 0.003).