Fig 1.
Flowchart of Study Selection.
Table 1.
Characteristics of 20 included studies (studies are sorted by year and month of publication).
Table 2.
BDNF levels of different point times and antidepressant treatment.
Fig 2.
Meta-Analyses for the levels of BDNF pre- and post- antidepressant drugs treatment (less than 12 week).
Fig 3.
Meta-Analyses for the improvement of depressive symptoms after ADs (less than 12 week).
Fig 4.
Antidepressants- Stratified Subgroup Meta-Analyses.
Forest plots showing the summary effect sizes for levels of BDNF pre- and post- different kind of antidepressant drugs treatment (less than 12 week). (A) using SSRIs;(B) using SNRIs.
Fig 5.
Meta-Analyses for the levels of BDNF pre- and post- antidepressant with differenti drugs treatment (less than 12 week).
Forest plots showing summary effect sizes of differential antidepressants (venlafaxine, paroxetine, sertraline and escitalopram) on BDNF concentration changes
Fig 6.
Sample- Stratified Subgroup Meta-Analyses.
Forest plots showing the summary effect sizes for levels of BDNF pre- and post- antidepressant drugs treatment (less than 12 week) in serum (A) or plasma(B).
Fig 7.
Meta-Analyses for BDNF concentrations at different treatment time points during antidepressants treatment (less than 12 week).
Forest plots showing the summary effect sizes for BDNF concentration changes at 4 weeks, 6 weeks, 8 weeks, and 12 weeks.