Fig 1.
5-year follow-up schedule.
Fig 2.
ROC curves depicting the accuracy of the final CEA value (left) and any rise above threshold (right).
The sensitivities and specificities achieved at thresholds of 2.5, 5, 7.5 and 10μg/L are highlighted.
Fig 3.
Time-dependent ROC curves depicting the accuracy of the final CEA value (left) and any rise above threshold (right).
Table 1.
Comparison of the diagnostic performance in detecting recurrence of a rise in blood CEA level above a threshold of 5μg/L in relation to i) all CEA measurements taken prior to diagnosis of recurrence and ii) the final CEA measurement taken prior to diagnosis of recurrence.
Table 2.
Estimated operational performance of CEA in clinical practice at currently recommended intervals if further investigation is triggered by thresholds of 2.5 and 5 μg/L.