Table 1.
Performance comparison of 18F-FDG and 68Ga-DOTATATE.
Table 2.
Contingency table categorizing the diagnostic accuracy of 18F-FDG and 68Ga-DOTATATE PET/CT with McNemar’s chi-square test.
Table 3.
Summary of imaging characteristics (30 patients, 31 lesions).
Fig 1.
68Ga-DOTATATE (A-D) and 18FDG PET/CT (E-H) concordant staging stage IIIB squamous cell carcinoma.
Concordant uptake in the right upper lobe tumor, right hilum and mediastinal adenopathy. Axial CT images (A&E) at mid chest with emission (C&G) and fused images (B&F). Anterior 3D maximum intensity images, D&H.
Fig 2.
Discordant image, FP 18F-FDG, TN 68Ga-DOTATATE PET/CT.
Axial CT (A) with a spiculated IPN. Fused 18F-FDG PET/CT (B) with IPN intense uptake (SUVmax 5.8) vs. 68Ga-DOTATATE (C) with no visible uptake (SUVmax 0.90). Comparison ratios of the SUVmax of the nodule to normal lung and aortic blood pool for 18F-FDG were 11.8 and 6.4, respectively, with corresponding values of 68Ga-DOTATATE being 2.2 and 1.5. Biopsy revealed inflammatory cells; nodule resolved on CT follow-up.
Table 4.
SSTR2 IHC staining results—12 biopsies.
Fig 3.
Inflammatory cells within non-neuroendocrine tumor.
A. Hematoxylin and eosin stain of squamous cell carcinoma (black arrows) with abundant plasma cells. B. SSTR2A IHC stain showing negative tumor staining (black arrows) but positive staining in inflammatory cells (original magnification 100X). C. High power field shows tumor (black arrows) with SSTR2A IHC membranous staining in plasma cells (white arrows).