Fig 1.
A schematic of the aortic wall including the aortic lumen, the intima, media, and adventitia.
Fig 2.
Interaction network among cells and cytokines in their respective layers.
SMCs remain in the media, and fibroblasts remain in the adventitia.
Fig 3.
Schematic representation of a 2D section of the computational domain.
ΩB is blood vessel; ΩM represents the media and ΩA the adventitia; ΓA, ΓB and ΓM are three free boundaries. ΓB is the inner surface of the artery, ΓA is the outer surface, and ΓM is the surface between the media and adventitia.
Table 1.
The variables of the model; concentration and densities are in units of g/cm3.
Fig 4.
Simulation results over 500 days.
The parameter used are as in Tables 2 and 3 with I60 = 6 × 10−9 g/ml.
Fig 5.
Aneurysm deformation at day 500 with initial deformation shown in (A). The parameters used are as in Tables 2 and 3 with (B) I60 = 6 × 10−9 g/ml, and (C) I60 = 6 × 10−8 g/ml. The diameter grows from 2 cm to 2.5 cm in case (B), and to 4.5 cm in case (C).
Fig 6.
The x-axis scales I60 from 6 × 10−9 g/ml to 6 × 10−8 g/ml; the y-axis scales R0 from 2 cm to 3 cm; The color represents the diameter of aortic bulge at 300 day.
Fig 7.
The x-axis scales I60 from 6 × 10−9 g/ml to 6 × 10−8 g/ml; the y-axis scales R0 from 2 cm to 3 cm; The color represents the diameter of aortic bulge at 500 day.
Table 2.
Parameters’ description and value.
Table 3.
Parameters’ description and value.