Table 1.
Subject demographics and TBI injury profiles.
Table 2.
Neuropsychological performance of TBI group.
Table 3.
Motion correction summary.
Table 4.
VBM analysis: Volume ratio.
Fig 1.
fMRI data preprocessing steps and the analytic pipeline.
Table 5.
Summary of graph network metrics (mean; sd).
Fig 2.
Results of 3D lesion modeling for TBI subjects at Time 1 (approximately 3-months post injury).
Total network cost and the lesion volume are not significantly correlated at Time 1, Time 2, or Time 3.
Fig 3.
Illustrates cost-efficiency relationship of group-averaged TBI network at all 3 time points (see Section 3.1.4 for details).
For cost bands 50000–100000, 100000–150000, and 150000–20000, there was a significant difference between the Time-2 and Time-3 efficiency values based on independent sample t-test. The Bonferroni corrected p-values and Cohen's-d for all cost bands are as follows, 0–50000 (p-value = 0.61, cohen's-d = 0.04), 50000–100000 (p-value << 0.05, cohen's-d = 0.30), 100000–150000 (p-value << 0.05, cohen's-d = 0.54), 150000–200000 (p-value << 0.05, cohen's-d = 0.70), and 200000–250000 (p-value = 1, cohen's-d = 0.06).
Table 6.
Hyperconnected and hypoconnected sub-systems for Time 2 TBI compared to HCs.
Fig 4.
Hyper- and hypo-connected sub-systems in the brain found using local analysis (see Section 3.2.1 for details).
Table 7.
High cost brain sub-systems for Time 2 TBI compared to HC sample.
Fig 5.
2-D histograms represent the distribution of connections that are incident upon ROIs within left frontal DMN (top) and Right Ventral Temporal/Parietal Attention (bottom) as a function of connection length and connection strength.
A contour line (e.g. contour line of cost = 80) represents all possible values of connection distance and connection strength that can produce the same cost value (distance*strength).