Fig 1.
The possible relationship between the MIA complex and ECF/ICF volumes.
As an integrated marker of fluid volume overload and malnutrition, the ECF/ICF ratio might be highly-related to the MIA complex, and can be a major risk indicator of morbidity and mortality in chronic hemodialysis patients.
Table 1.
Baseline characteristics of the study population.
Table 2.
Comparisons according to the cut-off ECF/ICF ratio.
Table 3.
Comparisons of the MIA components and fluid volume statusaccording to the cut-off ECF/ICF ratio.
Table 4.
Correlations (r) between the various fluid volume ratios and the individual MIA components and plasma BNP.
Fig 2.
All-cause and CVD free survival according to the ECF/ICF ratio.
A higher ECF/ICF ratio (≥0.57) was associated with a significantly lower all-cause and CVD free survival (log rank P<0.001). CVD, cardiovascular disease; ECF/ICF, extracellular fluid/intracellular fluid.
Table 5.
Unadjusted univariate and adjusted multivariate Cox proportional hazard model 1 for all-cause mortality and new CVD; Model 1 is composed of the 3 MIA components, fluid volume marker (plasma BNP), and ECF/ICF ratio.
Table 6.
Unadjusted univariate and adjusted multivariate Cox proportional hazard model 2 for all-cause mortality and new CVD.
In model 2, with other major cardiovascular risk factors, the ECF/ICF ratio (instead of individual MIA components and plasma BNP) was included as an integrated marker reflecting both the MIA complex and fluid volume status.