Fig 1.
Decision tree comparing 5 strategies for the treatment of second recurrence of community-onset Clostridium difficile infection.
Note: expanded model details shown for vancomycin pulse/taper arm only. Abbreviations: CDI: Clostridium difficile infection; FMT: fecal microbiota transplantation.
Table 1.
Base case estimates, range, and distribution for model variables.
Table 2.
Base case analysis of competing strategies for the management of second recurrence of community-onset Clostridium difficile infection.
Fig 2.
Tornado diagram, FMT via enema versus pulsed-tapered vancomycin.
Name of the variable (lower bound of the parameter—higher bound of the parameter [base case]). The ICER corresponding to the lower parameter bound is shown in black, while the ICER corresponding to the higher parameter bound is shown in grey. This figure represents the impact of the uncertainty of six parameters on the base case results. Abbreviations: CDI: Clostridium difficile infection; FMT: fecal microbiota transplantation; ICER: incremental cost-effectiveness ratio.
Fig 3.
Acceptability curve of treatments of second recurrence of Clostridium difficile infection.
This figure illustrates the proportion of the time each treatment was cost-effective at different willingness-to-pay thresholds. Abbreviations: FMT: fecal microbiota transplantation.