Fig 1.
The reaction scheme for the synthesis of 2-([1,1'-biphenyl]-4-yl)-2-oxoethyl benzoates, 2(a-q), and 2-([1,1'-biphenyl]-4-yl)-2-oxoethyl pyridinecarboxylate, 2r&2s.
Fig 2.
General scheme of biphenyl esters with torsion angles τ1, τ2, τ3 and τ4.
Table 1.
Summary of torsion angles*.
Fig 3.
Partial crystal packing of 2d and 2o and their overlay diagram.
Table 2.
Summary of structural occupancy of present and reported compounds.
Fig 4.
Structural occupancy comparison of biphenyl benzoates, phenacyl benzoates and adamantyl benzoates.
Fig 5.
The percentage of tyrosinse inhibition (mean±SD) with n = 3.
# and * indicate p<0.05.
Fig 6.
(a) Kojic acic binding mode in the crystal structure of TyrBm. Putative binding mode inside the binding gorge of TyrBm of ligands: (b) 2i, (c) 2o, (d) 2p, (e)2r and (f) 2s.