Fig 1.
Flowchart showing selection of the current study sample from the original 1953 Metropolit Copenhagen Birth Chohort. † defined as standardized residual exceeding ±3 ‡ Excluded according to predefined exclusion criteria (alcohol and drug abuse, major psychiatric and neurologic disease, major structural brain lesions, and contraindications to MRI).
Table 1.
Study population characteristics.
Fig 2.
Effect of hemoglobin on regional CBF.
Glass brain representation of voxels in absolute CBF maps with significant (p<0.001) negative correlation with blood hemoglobin. Brain volume covered by the ASL measurements is shown in the red box.
Table 2.
Whole brain magnetic resonance imaging results.
Fig 3.
The relationship of group with regional cerebral blood flow.
Voxels in absolute cerebral blood flow maps with significant (p<0.05, corrected for multiple comparisons) negative correlation with group (Group B<Group A), adjusted for homocysteine and hemoglobin.
Fig 4.
The relationship of brain parenchymal fraction with regional cerebral blood flow.
Voxels in cerebral blood flow maps with significant (p<0.05, corrected for multiple comparisons) positive correlation with brain parenchymal fraction, adjusted for group, homocysteine and hemoglobin.
Table 3.
The association (β coeffiecents) of subclinical cognitive decline with regional and global cerebral blood flow.