Table 1.
Survival analyses ALU-J/Sx content group N’s and ALU-J/Sx content ranges.
Table 2.
Participant characteristics.
Fig 1.
Age-associated ALU element instability and survival.
(a, b) ALU-J/Sx content per genome normalized to young adult group mean with SDs presented (F-test: ★P < 0.001), and (c, d) percent survival of elderly adults predicted by ALU-J/Sx content over four years (★P = 0.03; WBC-HR = 3.40, CI = 0.95–12.18; SMC-HR = 1.02, CI = 0.30–3.54). Terms—gDNA: genomic DNA; SD: standard deviation; ALU-J/Sx content: combined ALU-J and ALU-Sx content; WBC: white blood cells; SMC: smooth muscle cells; HR: hazard ratio; CI: confidence interval.
Table 3.
Assessment of 90% and 99% CI overlap of age-group comparison SDs.
Fig 2.
ALU element instability and cause-specific survival.
(a, b) CVD-associated percent survival of elderly adults predicted by ALU-J/Sx content over four years (★P = 0.03; WBC-HR = 4.21, CI = 0.90–19.70; SMC-HR = 0.84, CI = 0.19–3.70), and (c, d) cancer-associated percent survival of elderly adults predicted by ALU-J/Sx content over four years (WBC-HR = 0.74, CI = 0.05–12.28; SMC-HR = 2.07, CI = 0.22–20.00). Terms—CVD: cardiovascular disease; ALU-J/Sx content: combined ALU-J and ALU-Sx content; WBC: white blood cells; SMC: smooth muscle cells; HR: hazard ratio; CI: confidence interval.