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Table 1.

Clinical and pathological parameters of CCRCC patients (n = 59).

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Fig 1.

FAP immunohistochemical expression in primary and metastatic CCRCC.

Clear cell renal cell carcinoma arranged in nests (A) show FAP-positive cancer-associated fibroblasts delineating tumor lobes (B). Lymph node metastatic tumor growing more diffusely without recognizable architecture (C) displays FAP-positive cancer-associated fibroblasts intimately intermingled with tumor cells (D).

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Table 2.

Clinical and pathological variables and FAP expression in primary tumors.

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Table 2 Expand

Table 3.

Clinical and pathological variables and FAP expression in metastases.

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Table 3 Expand

Fig 2.

Kaplan-Meier survival curves for FAP expression in primary (A) and metastatic (B) clear cell renal cell carcinomas.

10-year overall survival showed significant differences between FAP protein positive and negative cases in primary tumors (log-rank test p<0.05).

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Table 4.

Univariate and Multivariate analyses to predict overall survival of mCCRCC patients.

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Table 4 Expand