Fig 1.
Consort 2010 flow diagram.
Fig 2.
Opaque corneal clouding of grade 4 in patient suffering from MPS I.
Fig 3.
Cornea verticillata grade 3 in patient suffering from Morbus Fabry.
A bilateral, whorl-like pattern of powdery, white, yellow or brown corneal deposits.
Table 1.
Grade of corneal clouding in the right (OD) and left (OS) eyes in all study groups.
Table 2.
Mean (estimated from linear mixed effects model) and corresponding 95% confidence interval of BCVA (decimal), spherical equivalent refraction (SEQ) and p-values.
Table 3.
Mean (estimated from linear mixed effects model) and corresponding 95% confidence interval of Goldmann applanation tonometry (GAT), corneal compensated intraocular pressure (IOPcc), Goldmann-correlated intraocular pressure (IOPg), central corneal thickness (CCT), corneal hysteresis (CH), corneal resistance factor (CRF) and corneal density.
Table 4.
Effects of diagnostic group and corneal clouding: p-values.
Fig 4.
Association of GAT, IOPcc, IOPg, CH, CRF, CCT and density with diagnostic group and the grade of the corneal clouding.
Estimated means and 95% confidence intervals are shown.
Table 5.
The Spearman correlation coefficients evaluated between IOP-measurements: Goldmann applanation tonometry (GAT), corneal compensated intraocular pressure (ccIOP), Goldmann correlated intraocular pressure (IOPg) and corneal biomechanical parameters: central corneal thickness (CCT), corneal hysteresis (CH), corneal resistance factor (CRF), corneal density and the grade of corneal opacity in all study groups.
Fig 5.
Association between Goldmann applanation tonometry (GAT), corneal compensated IOP (IOPcc), Goldmann correlated IOP (IOPg), corneal hysteresis (CH), corneal resistance factor (CRF) central corneal thickness (CCT), corneal density and the grade of corneal clouding in all experimental groups.
Estimated means and 95% confidence intervals are shown.
Fig 6.
Bland-Altmann Plot for agreement between Goldmann applanation tonometry (GAT) and corneal-compensated IOP (IOPcc).
Fig 7.
Bland-Altmann Plot for agreement between Goldmann applanation tonometry (GAT) and Goldmann-correlated IOP (IOPg).
Fig 8.
Bland-Altmann Plot for agreement between Goldmann applanation tonometry (GAT) and palpatory assessed IOP (palp IOP).
Table 6.
Mean values, standard deviations (SD) and p-values of Goldmann applanation tonometry (GAT), corneal compensated intraocular pressure (ccIOP), Goldmann correlated intraocular pressure (IOPg), palpatory assessed IOP (palp. IOP), central corneal thickness (CCT), corneal hysteresis (CH), corneal resistance factor (CRF) and corneal density for the right (OD) and left eyes (OS) in MPS I-IV.
Fig 9.
Goldmann applanation tonometry (GAT), corneal compensated IOP (IOPcc), Goldmann-correlated IOP (IOPg), corneal resistance factor (CRF), central corneal thickness (CCT) and corneal hysteresis (CH) in MPS type IV, VI and healthy controls in the right (OD) and the left (OS) eyes.