Fig 1.
(A) Average brain time-activity curve used to quantify CMRglc. (B) Example of Patlak linearization using a scaled SAIF.
Table 1.
Coefficients of correlation between the radioactivity concentration of plasma samples and the area under the curve of the full arterial input functions.
Fig 2.
AIF (red) and SAIF (black) in two non-fasting mice.
(A) Example of SAIF curve which is very similar to the blood reference curve (m17464). This SAIF is representative of the majority of the curves obtained in this study. There is however a significant number of AIF curves whose shape is incorrectly estimated by SAIF. (B) Example of AIF curve whose shape is incorrectly estimated by SAIF (m10911). One of the possible reasons is the difficulty of obtaining a reproducible bolus in the small tail vessels of mice. The insets magnify the first 10 minutes of the input functions.
Table 2.
Ratio between the CMRglc values obtained with SAIF and the reference values obtained with AIF.
Both populations of mice (fasting and non-fasting) show numerous estimation errors.