Fig 1.
Example of perfusion parameter calculation using the software.
(a). Early contrast enhanced T1 WI with fat suppression shows left breast cancer (arrowhead). A volume of interest (VOI) covering whole tumor area was semiautomatically drawn on the early contrast enhancement phase images in pink. (b-d). The VOI was copied to the corresponding Ktrans–, kep–, and ve–based perfusion map.
Fig 2.
Scatterplot of ve vs. angiogenic factor.
Correlation between microvessel density (MVD) and ve50 is positive (r = 0.33).
Table 1.
Correlation between perfusion parameters and angiogenesis factors.
Table 2.
Correlation between various perfusion parameters and conventional prognositc factors.
Table 3.
Correlation between various perfusion parameters and molecular markers and subtypes.
Fig 3.
A 44 year-old woman with large tumor size, high Ktrans and microvessel density (MVD).
(a). Maximal intensity projection image of early contrast phase enhancement phase shows a 4.9 cm sized invasive ductal carcinoma in right breast. Two neighboring masses are connected on pathology. (b). Ktrans map demonstrates red color on the tumor (Ktrans50 = 0.568) (c). Photomicrograph with CD34 shows vascular endothelium staining as dark brown (microvessel density 86) (Original magnification X200).
Table 4.
Multiple linear regression analysis of perfusion parameters and angiogenesis, prognostic factors.
Table 5.
Correlative studies between perfusion parameters and angiogenesis factors.
Table 6.
Correlative studies between perfusion parameters on breast DCE MRI and prognostic factors.