Fig 1.
Transport and mechanism of action of doxorubicin.
Table 1.
Amplification refractory mutation system (ARMS) and standard-PCR primers for genotyping and sequencing of ABCB1 (rs10276036 C/T) and SLC22A16 (rs12210538 A/G) gene polymorphisms.
Fig 2.
Fig 2A. Agarose gel image of the amplification refractory mutation system-PCR products of the ABCB1 gene polymorphism (rs10276036 C/T). 1: 50 bp DNA ladder, 2 & 3: heterozygote allele C/T, 4 & 5: homozygote allele C, 6 & 7: homozygote allele T, 8 & 9: negative control for alleles C and T respectively, Fig 2B. Electropherogram of the ABCB1 gene polymorphism (rs10276036 C/T) homozygote allele C, Fig 2C. Electropherogram of the ABCB1 gene polymorphism (rs10276036 C/T) homozygote allele T, Fig 2D. Electropherogram of the ABCB1 gene polymorphism (rs10276036 C/T) heterozygote allele C/T, Fig 2E. Agarose gel image of the amplification refractory mutation system-PCR products of the SLC22A16 gene polymorphism (rs12210538 A/G). 1: 50 bp DNA ladder, 2 & 3: heterozygote allele A/G, 4 & 5: homozygote allele A, 6 & 7: homozygote allele G, 8 & 9: negative control for alleles A and G respectively, Fig 2F. Electropherogram of the SLC22A16 gene polymorphism (rs12210538 A/G) homozygote allele A, Fig 2G. Electropherogram of the SLC22A16 gene polymorphism (rs12210538 A/G) homozygote allele G, Fig 2H. Electropherogram of the SLC22A16 gene polymorphism (rs12210538 A/G) heterozygote allele A/G.
Table 2.
Demographic characteristics of the cohorts.
Table 3.
Allele and genotype analysis of the ABCB1 gene polymorphism (rs10276036 C/T).
Table 4.
Allele and genotype analysis of the SLC22A16 gene polymorphism (rs12210538 A/G).
Table 5.
Clinical characteristics of the patients.