Fig 1.
Average double logistic fitted curves showing the circadian variation of systolic and diastolic blood pressure, heart rate and behavioural activity over a 24-hour period from 10 SHR before (open circles) and after (filled circles) treatment with rilmenidine for 2 weeks.
Curves were constructed using the average parameters of double-logistic curve fitting procedure. Error bars indicate SEM of hourly averages.
Table 1.
Average results from the circadian analysis of 24-hour blood pressure measurements in rats treated with rilmenidine.
Table 2.
Average results from the circadian analysis of 24-hour blood pressure measurements in rats treated with Perindopril.
Fig 2.
Average double logistic fitted curves showing the circadian variation of systolic and diastolic blood pressure, heart rate and behavioural activity over a 24-hour period from 8 SHR before (open circles) and after (filled circles) treatment with perindopril for 2 weeks.
Curves were constructed using the average parameters of double-logistic curve fitting procedure. Error bars indicate SEM of hourly averages.
Table 3.
Average results from the circadian analysis of 24-hour blood pressure measurements in rats treated with Vehicle.
Fig 3.
Average double logistic fitted curves showing the circadian variation of systolic and diastolic blood pressure, heart rate and behavioural activity over a 24-hour period from 11 SHR before (open circles) and after (filled circles) treatment with vehicle for 2 weeks.
Curves were constructed using the average parameters of double-logistic curve fitting procedure. Error bars indicate SEM of hourly averages.
Fig 4.
Average double logistic fitted curves showing the circadian variation of systolic and diastolic blood pressure, heart rate and behavioural activity over a 24-hour period from 11 SHR before (open circles) and after (filled circles) treatment with vehicle for 2 weeks.
Curves were constructed using the average parameters of double-logistic curve fitting procedure. Error bars indicate SEM of hourly averages.
Fig 5.
Upper: Average mid frequency (MF, 0.25–0.6 Hz) MAP power (mmHg)2, MF HR power (bpm)2, Middle: Coherence (units), baroreflex gain, (gain, bpm/mmHg), Lower: low frequency (LF, 0.05–0.25 Hz) and high frequency (HF, 0.6–1.0 Hz) MAP power (mmHg)2 from cross spectral analysis during the light (inactive) phase (left bars white), and dark (active) phase (right bars, shaded).
Measurements are 2 weeks after vehicle (V, open bars), perindopril (P, hatched bars) and rilmenidine (R, crosshatched bars) in SHR (n = 7–9 per group). Values are mean ± SEM. Effect of perindopril or rilmenidine compared with vehicle *, P<0.05; **, P<0.01; ***, P<0.001.