Fig 1.
ABCD The time course of the availability of four macronutrients and variability of R in the period 1929–2005. A Fat total, B Carbohydrates, C Protein, D Alcohol total.
Fig 2.
Flow chart 1 of the rationale applied in this paper.
Fig 3.
Flow chart 2 optimization of precedence periods.
Table 1.
Regression coefficients for macronutrients without alcohol (A) and with alcohol (B) and their corresponding periods of precedence in years.
Fig 4.
Flow chart 3 optimization of macronutrient proportions.
Table 2.
The values (positive or negative) of macronutrient coefficients and the strength of the influence (in %) of each macronutrient without alcohol (A) and with alcohol (B) in each model.
Bold font indicates the nutrient with the highest influence on Rpredicted.
Table 3.
Parameters of goodness of fit for models without alcohol (A) and with alcohol (B).
Fig 5.
Wheel charts of the proportions of macronutrients in the energy units for each period studied.
Table 4.
Comparison of the mean availability of macronutrients in the corresponding periods of precedence with predicted optimal proportions of macronutrients in grams per day assuming 2000 kcal diet.
Calculated from models without alcohol and with two levels of alcohol consumption: 12.5 or 25 g pure ethanol daily corresponding to half or one standard drink a day, respectively.
Fig 6.
R2 adjusted for 7 studied statistical models.