Fig 1.
Graphical user interface on T2-weighted MR image with two small white boxes indicating an example voxel for tumor (left) and control tissue (right) within the measured area (large white box) (A). Corresponding T1-weighted contrast enhanced MR image (B).Corresponding spectra for the marked tumor (C) and control tissue voxels (D). The original signal is shown in black, the LCModel fit in red and the isolated signal for myoinsitol in blue. A * marks the creatine peaks.
Table 1.
Patient characteristics.
Fig 2.
(A) Box-Whisker-plot showing the median (baseline CCNU/VM26 = 2.73, BVZ = 2.47; post treatment CCNU/VM26 = 2.38, BVZ = 3.61) and quartiles for tumor at baseline and post treatment for BVZ (orange) and CCNU/VM26 (blue). (B) Box-Whisker-plot showing the median (baseline CCNU/VM26 = 4.83, BVZ = 4.97; post treatment CCNU/VM26 = 4.83, BVZ = 6.08) and quartiles for the control tissue at baseline and post treatment for BVZ (orange) and CCNU/VM26 (blue). Each * marks a significant increase from baseline to post treatment.
Table 2.
Results.
Fig 3.
Kaplan-Meier-Curves based on control tissue MI.
Kaplan-Meier-Curves for patients with a MI concentration in the control tissue at baseline > 4.696 (OS 270 days, color: red) compared to patients with a MI concentration < 4.696 (median overall survival (OS 206 days, color: brown).The figure shows an extract with an OS of 1829 days for the remaining patient of the brown cohort and a censored survival of 1424 days for the remaining patient in the red cohort. MI = Myoinositol; OS = overall survival; delta MI = MI control tissue minus tumor concentrations at baseline.
Fig 4.
Kaplan-Meier-Curves based on delta MI.
Kaplan-Meier-Curves for patients with delta MI values > 1.817 (OS 275 days, color: red) compared to patients with values < 1.817 (OS 164 days, color: brown). The figure shows an extract with an OS of 1829 days for the remaining patient of the brown cohort and a censored survival of 1424 days for the one remaining patient in the red cohort. MI = Myoinositol; OS = overall survival; delta MI = MI control tissue minus tumor concentrations at baseline.