Table 1.
Baseline characteristics of the thyroid nodules with architectural atypia.
Table 2.
Final pathologic diagnoses of the thyroid nodules with architectural atypia.
Fig 1.
Radiologic and pathologic findings of the representative case.
(A) Ultrasonography showed a 2.8 cm sized isoechoic thyroid nodule in the right upper lobe. This nodule was biopsied using spring-activated core needle. (B) The core needle biopsy specimen showed histological features of suspicious follicular neoplasm with microfollicular proliferation and thin tumor capsule. (C-D) Hemithyroidectomy specimen grossly revealed totally encapsulated 3 cm sized round nodule in the right lobe (C, arrow) and histologically demonstrated invasive encapsulated follicular variant papillary thyroid carcinoma with definite capsular invasion (D).
Fig 2.
Malignancy rate of thyroid nodules with architectural atypia.
(A) The malignancy rate was estimated to be 7–35% in AUS-A nodules and 28–49% in FN/SFN nodules. (B) After reclassification of follicular variant papillary thyroid carcinomas to non-invasive thyroid neoplasm with papillary-like nuclear features, the malignancy rate was estimated to be 5–24% in AUS-A nodules and 23–39% in FN/SFN nodules. (AUS-A, atypia of undetermined significance with architectural atypia; FN/SFN, follicular neoplasm/suspicious for a follicular neoplasm).
Table 3.
Factors associated with malignancy of thyroid nodule with architectural before and after reclassification.
Table 4.
Association between preoperative factors and subtypes of follicular variant papillary thyroid carcinomas.